SnapShot: The SUMO System

SnapShot: The SUMO System

Snapshot on the EDOS Distribution System

The open-source software communities currently face an increasing complexity of managing the software content among theirs developers and contributors. This is mainly due to the continuously growing size of the software, the high frequency of the updates, and the heterogeneity of the participants. We propose a distribution system that tackles two main issues in the software content management: ...

A Snapshot of the Nervous System

The nervous system enables humans to process and respond to external and internal information. It is comprised of two major components: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS includes the brain and spinal cord, which are both enclosed in bone (the skull and the vertebrae) and surrounded by cerebrospinal fluid (CSF). The PNS consists of spinal nerves (o...

The small ubiquitin-like modifier (SUMO) and SUMO-conjugating system of Chlamydomonas reinhardtii.

The availability of the complete DNA sequence of the Chlamydomonas reinhardtii genome and advanced computational biology tools has allowed elucidation and study of the small ubiquitin-like modifier (SUMO) system in this unicellular photosynthetic alga and model eukaryotic cell system. SUMO is a member of a ubiquitin-like protein superfamily that is covalently attached to target proteins as a po...

Viral control of the SUMO pathway: Gam1, a model system.

SUMO (small ubiquitin-related modifier) is a ubiquitin-like family member that is conjugated to its substrates through discrete enzymatic steps: activation, involving the E1 enzyme [SAE (SUMO-activating enzyme) 1-SAE2], conjugation, involving the E2 enzyme [Ubc9 (ubiquitin-conjugating enzyme 9)], and substrate modification, through the co-operation of Ubc9 and E3 protein ligases. Work from our ...